Document Details
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Document Type |
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Thesis |
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Document Title |
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VITAMIN D STATUS IN SAUDI FEMALED WITH GESTATIONAL DIABETES مستوي فيتامين د لدي سيدات سعوديات مصابات بسكر الحمل |
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Subject |
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Faculty of medicine |
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Document Language |
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Arabic |
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Abstract |
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Vitamin D deficiency is elevated in incidence and has become a major public health problem. Measuring vitamin D values in pregnant women is not a routine test. As a result, many women go undetected and do not get the appropriate treatment, predisposing them and their fetus to develop several symptoms of deficiency. Assessing vitamin D levels in women who are at risk of deficiency can help recognize those who are deficient and are in need of vitamin D supplementation. Incompatible results currently found on the association between vitamin D and glucose metabolism. The role of maternal vitamin D status in gestational diabetes mellitus (GDM) remains unclear, prevention and treatment strategies are often inadequate. Thus, we aimed to assess the association of vitamin D deficiency in pregnant women with GDM compared with pregnant women with normal glucose tolerance.
A total of 120 pregnant women in their second trimester, divided into two equal groups (60 GDM and 60 healthy controls) were randomly recruited from King Abdul-Aziz University Hospital (KAUH). The study individuals were interviewed with a questionnaire to estimate medical history, medication use, lifestyle and dietary habits. The anthropometric variables were measured for the fetuses as follows: body weight, height and head circumference. In addition, blood samples were taken from all study individuals to determine the following biochemical parameters: serum vitamin 25(OH) D, calcium, phosphate, magnesium, parathyroid hormone, alkaline phosphatase, hemoglobin A1c, vitamin B12, C-peptide and glucose levels. It was observed that, serum vitamin D level was not significantly reduced in GDM compared to controls during pregnancy (p>0.05). In addition, both groups of pregnant women exhibited high prevalence of vitamin D deficiency (83% of controls and 93% of cases). This is associated with poor glycemic control as reflected by inverse correlation between serum levels of vitamin D and HbA1c (r= - 0.245, p<0.01). Furthermore, significant inverse relationships between serum vitamin D levels and all foetal radiological measurements were found. Low maternal vitamin D levels may be associated with elevated risk of GDM, but our findings are also influenced by coexisting risk factors, such as obesity, which might lead to both low vitamin D levels and GDM independently. Nevertheless, further clinical studies are required to confirm these results. |
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Supervisor |
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Prof. Eman Alissa |
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Thesis Type |
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Master Thesis |
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Publishing Year |
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1439 AH
2018 AD |
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Co-Supervisor |
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Prof. Mohamed Ardawi |
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Added Date |
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Thursday, April 26, 2018 |
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Researchers
| هبه هشام باحمدان | Bahmdan, Hiba Hisham | Researcher | Master | |
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