Document Details

Document Type : Thesis 
Document Title :
Vitamin D binding protein (DBP) role in the development of cardiovascular diseases in hemodialysis patients
دور البروتين الملازم لفيتامين د فى تطور أمراض القلب والأوعيه الدمويه فى مرضى الغسيل الكلوى
 
Subject : Biochemistry department 
Document Language : Arabic 
Abstract : Introduction/Aim: Several studies have demonstrated that patients with chronic kidney disease (CKD) on dialysis or pre-dialysis are 25(OH)D deficit and have an increased risk of cardiovascular mortality. However the exact mechanism has not yet been completely elucidated. Two protein molecules have been associated with the development of atherosclerotic plaque, namely vitamin D-binding protein (DBP), and myloperoxidase (MPO). In the present study, we aim to investigate whether the addition of DBP and MPO to conventional biochemistry tests of cardiovascular disease could improve detection of absolute coronary risk in patients with CKD on hemodialysis as compared with non-hemodialysis patients. Methods : Plasma-vitamin-D, DBP and MPO concentrations were quantified using enzyme-linked immune-sorbent assay (ELISA) in 60 patients and 20 healthy controls. Biochemistry parameters for cardio-metabolic and bone-metabolism markers were also measured and correlated with DBP. Result : In the present study, we observed a reduction in vitamin D serum concentration compared with control group; however, this change did not reach statistical significance (29.01 ± 18.01 vs. 36.3 ± 10.11). Vit.D. showed no correlations with any studied parameter. Mean while, we found the concentrations of serum DBP was significantly (P<0.014) lower in patients with HD-ESRD patients than control group. In addition; a negative correlation between serum DBP and creatinine (p<0.001), CKMB (P<0.04), PTH (P<0.0001), Mg (P<0.008) and age (0.0001). Whereas, DBP showed significant positive correlation with ferretin (P<0.0001) and B12 (P<0.006). MPO on the contrary was not varied significantly in ESRD from controls, and it showed only a significant negative correlation with creatinine (P<0.012). Conclusions: Our results may suggest a close relation between DBP and kidney and heart functions, and that the addition of DBP to conventional biochemistry workup could be beneficiary for patients with ESRD undergoing hemodialysis whom has high risk for developing cardiac diseases. 
Supervisor : Dr. Mohamed F. Elshal 
Thesis Type : Master Thesis 
Publishing Year : 1434 AH
2013 AD 
Co-Supervisor : Dr. Abdurahman L.Al-Malki 
Added Date : Saturday, June 15, 2013 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبد العزيز سفران العرابيAl-Orabi, Abdulaziz SafranResearcherMaster 

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