Document Details

Document Type : Article In Journal 
Document Title :
Vascular and cellular events in post-mastectomy seroma: An immunohistochemical study
Vascular and cellular events in post-mastectomy seroma: An immunohistochemical study
 
Subject : General Surgery 
Document Language : English 
Abstract : This study aimed to describe the vascular and cellular histopathological changes that occurred in post-mastectomy seroma in an animal model. Unilateral mastectomies were conducted on 45 female albino rabbits. On day seven, the skin flap and the underlying tissues of the mastectomy regions were dissected and processed for histopathological examination using immunohistochemical staining of the T- and B-lymphocytes and macrophages (CD3, CD20, and CD68 respectively), and the vascular endothelia. The post-mastectomy regions in the seroma group showed a large number of inflammatory cells and newly formed blood vessels that lost the integrity of their endothelial cell linings, as revealed by the von Willebrand factor staining, as well the basement membrane, as revealed by the histochemical stain. The post-mastectomy seroma beds showed many CD3 and CD20+ve lymphocytes and CD68+ve macrophages. These macrophages were producing angiogenic factors, resulting in the persistent and continuous formation of new blood vessels. These new blood vessels were defective and represented an underlying cause of seroma formation 
ISSN : 0008-8749 
Journal Name : Cellular Immunology 
Volume : 272 
Issue Number : 2 
Publishing Year : 1433 AH
2012 AD 
Article Type : Article 
Added Date : Thursday, January 5, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
زهور الغيثيAl-Ghaithy, Zuhoor InvestigatorDoctorate 
نصرة أيوبAyuob, Nasra ResearcherDoctorate 

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