Document Details

Document Type : Article In Journal 
Document Title :
Synthesis of novel steroidal oxazolo quinoxaline as antibacterial agents
Synthesis of novel steroidal oxazolo quinoxaline as antibacterial agents
 
Subject : Chemistry 
Document Language : English 
Abstract : Steroidal [oxazolo(4,5-b)quinoxaline-2-yl-hydrazone] derivative (7a-9a) (7b-9b) were prepared by the multi-step reactions of steroid. It is prepared via the reaction of steroidal semicarbazones with 2,3-dichloroquinoxaline at 80°C in ethanol. The structures of the compounds were evident by IR, 1H NMR and mass spectrometry and their purities were confirmed by elemental analyses. The antibacterial activity of these compounds was evaluated by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria and then the minimum inhibitory concentration (MIC) of compounds was determined. The results showed that compounds (7a, 7b, 8a, 8b) are better antibacterial agent as compared with the standard drug amoxicillin. 
ISSN : 1878-5352 
Journal Name : Arabian Journal of Chemistry 
Volume : 4 
Issue Number : 3 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Saturday, March 3, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
سلمان أحمد خانKhan, Salman AResearcherDoctoratesahmad_phd@yahoo.co.in
عبدالله محمد عسيريAsiri, Abdullah MohamedResearcherDoctorateaasiri2@kau.edu.sa

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