Document Details

Document Type : Article In Journal 
Document Title :
Synthesis and biological evaluation of new 3,5-di(trifluoromethyl)-1,2,4- triazolesulfonylurea and thiourea derivatives as antidiabetic and antimicrobial agents
Synthesis and biological evaluation of new 3,5-di(trifluoromethyl)-1,2,4- triazolesulfonylurea and thiourea derivatives as antidiabetic and antimicrobial agents
 
Subject : Chemistry 
Document Language : English 
Abstract : Fluorinated 1,2,4-triazoles 3 and benzenesulfonyl urea and thiourea derivatives as well as their cyclic sulfonylthioureas 4-10 were prepared as antimicrobial agents. The chemistry involves the condensation of sulfanilamide derivatives 1 with trifluoroacetic anhydride to give N-di(trifluoroacetyl) sulfonamides 2 which upon reaction with hydrazine hydrate afforded the corresponding triazole derivatives 3. Reaction of triazole derivative 3a with isocyanates and isothiocyanates gave the corresponding ureas 4 and thioureas 5. Cyclization of thiourea derivatives with ethyl bromoacetate, 1,2-diiodoethane, diethyl oxalate and α-bromoacetophenone derivatives yielded the corresponding 4-oxothiazolidines 7, thiazolidines 8, 4,5-dioxothiazolidines 9 and thiazolines 10. Preliminary biological screening of the prepared compounds revealed significant antimicrobial and mild antidiabetic activities. 
ISSN : 0022-1139 
Journal Name : Journal of Fluorine Chemistry 
Volume : 132 
Issue Number : 11 
Publishing Year : 1432 AH
2011 AD
 
Article Type : Article 
Added Date : Saturday, March 3, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
حسن مصطفى فيض اللهFaidallah, Hassan MostafaResearcherDoctorateHFAIDALLAH@kau.edu.sa
سلمان أحمد خانKhan, Salman AResearcherDoctoratesahmad_phd@yahoo.co.in
عبدالله محمد عسيريAsiri, Abdullah MohamedResearcherDoctorateaasiri2@kau.edu.sa

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