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Document Type |
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Article In Journal |
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Document Title |
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Synthesis and anti-bacterial activities of some novel schiff bases derived from aminophenazone Synthesis and anti-bacterial activities of some novel schiff bases derived from aminophenazone |
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Subject |
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Chemistry |
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Document Language |
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English |
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Abstract |
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A series of 1,5-dimethyl-2-phenyl-1,2-dihydro-3H-pyrazol-3-one-containing Schiff bases were synthesized, characterized and screened for their antibacterial activities. The structures of the synthesized compounds were established by spectroscopic (FT-IR, 1H-NMR, 13C-NMR, MS) and elemental analyses. The anti-bacterial activities (with MIC values) of compounds were evaluated. The anti-bacterial screening results reveal that among the six compounds screened, four compounds showed moderate to good antibacterial activity. Among the tested compounds, the most effective compounds against four bacterial strains, viz. Escherichia coli, Staphylococcus aureus, Salmonella typhimurium and Streptococcus pyogenes, are [(2-Chlorobenzylidene) amino]-1,5-dimethyl-2-phenyl- 1,2-dihydropyrazol-3-one (4) and [(1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol- 4-ylimino)methyl] benzonitrile (5) with MIC values of 6.25 μg/mL. |
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ISSN |
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1420-3049 |
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Journal Name |
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Molecules |
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Volume |
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15 |
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Issue Number |
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10 |
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Publishing Year |
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1431 AH
2010 AD |
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Article Type |
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Article |
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Added Date |
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Saturday, February 18, 2012 |
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Researchers
| عبدالله محمد عسيري | Asiri, Abdullah Mohamed | Researcher | Doctorate | aasiri2@kau.edu.sa |
| سلمان أحمد خان | Khan, Salman A | Researcher | Doctorate | sahmad_phd@yahoo.co.in |
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