Document Details

Document Type : Article In Journal 
Document Title :
Synthesis and anti-bacterial activities of a bis-chalcone derived from thiophene and its bis-cyclized products
Synthesis and anti-bacterial activities of a bis-chalcone derived from thiophene and its bis-cyclized products
 
Subject : Chemistry 
Document Language : English 
Abstract : A chalcone was prepared by the reaction of terephthalaldehyde with 3-acetyl-2,5-dimethylthiophene. Treatment of this chalcone with thiosemicarbazide/phenyl hydrazine/guanidine hydrochloride/thiourea afforded the corresponding pyrazoline, pyrazole, and pyrimidine in good yields. All the new compounds have been characterized by IR, 1H-NMR, 13C-NMR, GC-MS and elemental analyses. The anti-bacterial activity of these compounds were first tested in vitro by the disk diffusion assay against two Grampositive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) was determined with the reference of standard drug chloramphenicol. The results showed that the pyrazoline derivative is better at inhibiting growth of both types of bacteria (Gram-positive and Gram-negative) compared to chloramphenicol. 
ISSN : 1420-3049 
Journal Name : Molecules 
Volume : 16 
Issue Number : 1 
Publishing Year : 1432 AH
2011 AD 
Article Type : Article 
Added Date : Saturday, February 18, 2012 

Researchers

Researcher Name (Arabic)Researcher Name (English)Researcher TypeDr GradeEmail
عبدالله محمد عسيريAsiri, Abdullah MohamedResearcherDoctorateaasiri2@kau.edu.sa
سلمان أحمد خانKhan, Salman AResearcherDoctoratesahmad_phd@yahoo.co.in

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